[Effect of 1-tetrahydropalmatine on spontaneous electric discharge induced by chronic dorsal root ganglion neurons compression in rats].

Objective To study the effect of 1-tetrahydropalmatine(1-THP) on the spontaneous electric discharge(SED) induced by chronic dorsal root ganglion neurons compression.Methods Using single fiber recording method,the SED of 84 neurons class A induced by compression were recorded.The effect of 1-THP on the SEDs and its relation with concentration were observed.Results In the 84 SED of neurons,25 showed periodical rhythmicity(PR) and 59 showed non-periodic rhythmicity(non-PR).1-THP(100 μmol/L) inhibited SED in 16.0%(4/25) of neurons with PR and 67.8%(40/59) of neurons with non-PR(P0.01) in an effect-dose dependent manner,the higher the concentration of 1-THP,the more the inhibition,with quicker inhibiting initiation and longer time needed for recovery.SED in 57.1% neurons were recovered 20 min after elution,but unrecovered even after 3 h in the others.Conclusion 1-THP shows inhibitory effect on the A-fiber SED induced by chronic dorsal root ganglion neurons compression.