Maternal Obesity is Associated with Higher cord Blood Adipokines in Offspring most Notably in Females.

BACKGROUND Deleterious long-term effects in the offspring from women with pregravid obesity have been described. However, the evidence supporting early metabolic and inflammatory markers in the offspring at birth and gender differences are conflicting. OBJECTIVE This study aimed to compare cord blood adipokines and cytokines concentrations and anthropometric characteristics of the offspring of women with maternal obesity (MO) and normal-weight mothers (NWM). Also, maternal and neonatal variables on the association of maternal BMI with cord blood adipokines were evaluated. METHODS A cross-sectional analysis of a subsample of mother-child dyads participating in a cohort study (n = 221) was assessed. Anthropometrics, cord blood adipokines (leptin and adiponectin) and cytokines (IL-1β, IL-4, IL-10, IL-12 p40, IL-12p70, IL-13, and TNFα) concentrations in the offspring of normal-weight women (BMI >18.5 and ≤24.9 kg/m2) and women with pregravid obesity (BMI ≥30 kg/m2) without comorbidities was performed. RESULTS Offspring from mothers with obesity had higher birth weight, a higher proportion of large for gestational age, higher ponderal index, and heavier placentae than offspring from normal-weight mothers (p < 0.05). Within the offspring from women with obesity, males had significantly higher weight, length, the proportion of large-for-gestational-age newborns, higher weight for length ratio. Males had more efficient placentas than females (p < 0.05). Higher adiponectin and leptin in both sexes and higher leptin in female offspring of mothers with obesity after adjusting for birth size (p < 0.05) were found. Higher IL-12p40 in the offspring of women with MO with no other differences in other cytokines among groups were evidenced. CONCLUSIONS Maternal obesity associates with a higher concentration of adiponectin and leptin in their offspring at birth. There is a relevant effect on anthropometrics in male offspring and on leptin in the female newborn. Further studies need to evaluate the extension of these effects in postnatal life. TRAIL IDENTIFICATION NUMBER NCT02903134. An infographic is available for this article at:http://links.lww.com/MPG/C363.