Status of patients who underwent uninephrectomy in adulthood more than 20 years ago

Abstract We investigated the status of patients without systemic diseases who had undergone uninephrectomy for unilateral renal diseases in adulthood more than 20 years ago at Tokyo Denryoku Hospital. There were 21 participants (mean age ± SD, 58.6 ± 8.0 years) who fulfilled these criteria. The average interval since nephrectomy was 27.9 ± 6.2 years. The mean current creatinine clearance was 88.5 ± 21.2 mL/min/1.73 m 2 , which is 92.9% of that in healthy age- and sex-matched controls with two kidneys. The 24-hour urine protein excretion in these patients was only slightly higher than in the controls (214 ± 190 mg v 119 ± 62 mg, P = NS). Age at nephrectomy, length of time with a single kidney, or sex had little effect on the remnant renal functions. There was a positive correlation between current mean arterial pressure and serum creatinine ( r = 0.44, P v 29%, P