Enfermedad de Still del adulto: presentación de cuatro casos Adult onset Still's disease: presentation of four cases

Summary Adult onset Still’s disease (AOSD) is a rare systemic illness of unknown aetiology and which usually affects young adults. It is characterised by arthralgia, high peaking temperatures and a characteristic exanthema. Cutaneous lesions are salmon coloured erythematous urticariform macula located mainly on the trunk and extremities. These lesions are symptom free and appear as typically transitory evening eruptions with posterior fleeting resolution and follow a parallel course to the fever. Histologically, they show a perivascular inflammatory dermic infiltrate with lymphocitic predominance and containing some neutrophils. Rheumatoid factors and antinuclear antibodies are negative and leucocytosis with neutrophilia is seen on blood analysis. Other possible findings in AOSD are sore throat, lymphoadenopathies, splenomegalia or liver dysfunction, among others. AOSD in 4 females is presented describing cutaneous lesions, systemic involvement, histological results and evolution.