Anticonvulsant activity of 1-acyl-5-phenyl-3-pyrazolidinones

OBJECTIVETo study the anticonvulsant act ivity of thirteen 1-acyl-5phenyl-3-pyrazolidinones.METH ODSThe anticonvulsant activity was detected by the maximal electroshock seizur e, and the phenobarbital sodium and sodium valproate were compared.RES ULTSAmong the compound(01)～(05), the (05) showed better anticonvulsa nt activity and its ED 50 was 46 65mg/kg, and comparing with the lead compound, the anticonvulsant activity of the compound(06)～(10) had no marked prog ress. Among the three kinds of compounds, the compound(11)～(13)showed the best anticonvulsant activity, and the ED 50 of (13) was 10 07mg/kg.CONCLUSIONThe derivatives of 1- acyl-5phenyl-3-pyrazolidinone ha ve the better anticonvulsant activity.