Blood Pressure Management in Afferent Baroreflex Failure: JACC Review Topic of the Week

Highlights •Afferent baroreflex failure can cause severe supine hypertension, episodes of profound hypotension, and orthostatic hypotension, making it one of the most challenging forms of hypertension to manage. •Long-acting central sympatholytic drugs are the mainstay of treatment; short-acting agents should be avoided because of rebound hypertension. •More research is needed to validate treatment recommendations and develop preventive measures.