Refractory cold agglutinin-immunohaemolytic anaemia associated to marginal zone lymphoma responding to rituximab.

Coldagglutininimmunohaemolyticanaemia(CAIA)respondspoorlytostandardtreatment.WereportacaseofmarginalzonelymphomacomplicatedbyCAIAthatrespondedtorituximabafterfailingtorespondtocorticosteroidsandchlorambucil.The Hematology Journal (2003)4, 450–451.doi:10.1038/sj.thj.6200329Keywords: marginalzonelymphoma;coldagglutinindisease;immunohaemolyticanaemia;rituximab(CAIA) is far less common than warm-antibodyimmunohaemolyticanaemiaandmaycomplicatethecourseofB-celllymphomas,inwhichCAissupposedlyproduced by the malignant clone itself. In otherinstances,CAdisease(CAD)mayprecedethedevelop-ment of lymphoma. Immunologic abnormalities inmarginalzonelymphomaincludeautoimmunehaemo-lyticanaemia,