Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness

Background:The effects of hyperglycemia and insulin therapy on septic outcome have not been well studied.Methods:Septic hyperglycemia was induced by infusion of TPN (254 kcal/kg × d−1) immediately following cecal ligation and puncture (CLP) surgery in rats. Animals (N = 109) were monitored for blood