Single dose of Doxycycline for the prevention of TBRF

The current post-exposure prophylaxis regimen for Tick Borne Relapsing Fever (TBRF) consists of 5 days Doxycycline. In this observational study of 77 spelunkers at high-risk for TBRF, a single dose of 100 mg Doxycycline taken up to 72 hours after exposure to ticks was 100% effective in preventing the disease.