Mycoplasma Pneumoniae Infection Complicated by Paroxysmal Cold Hemoglobinuria with Anti-P Specificity of Biphasic Hemolysin

A 7-year-old boy with Mycoplasma Pneumoniae infection complicated by transitory paroxysmal cold haemoglobinuria (PCH) is described. The Donath-Landsteinerantibody exhibited anti-P specificity; hemolytic activity was partially inhibited against papainized erythrocytes at 0° C incubation temperature and increased from 8° C upwards. The association of Mycoplasma pneumoniae infection with PCH has been described 4 times only and in one instance where specificity was stated it was anti-I.