Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs

Emanuela Ricciotti,Cecilia Castro,Soon Yew Tang,William T. E. Briggs,James A. West,Dania Malik,Seth D. Rhoades,Hu Meng,Xuanwen Li,Nicholas F. Lahens,Jeffrey A. Sparks,Elizabeth W. Karlson,Aalim M. Weljie,Julian L. Griffin,Garret A. FitzGerald

Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs

2018

Emanuela Ricciotti
Cecilia Castro
Soon Yew Tang
William T. E. Briggs
James A. West
Dania Malik
Seth D. Rhoades
Hu Meng
Xuanwen Li
Nicholas F. Lahens
Jeffrey A. Sparks
Elizabeth W. Karlson
Aalim M. Weljie
Julian L. Griffin
Garret A. FitzGerald

Background: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective p...

Keywords:

Diabetes mellitus
Nitric oxide
Cyclooxygenase
Cardiology
Anti-inflammatory
Endothelium
Internal medicine
Asymmetric dimethylarginine
Kidney
Nonsteroidal
Pharmacology
Medicine

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