Effects of scopolamine upon hippocampal electrical activity associated with running and swimming in rats

Abstract In freely moving rats with implanted hippocampal electrodes, the influence of scopolamine HBr (5–10 mg/kg IP) on hippocampal rhythmic slow activity (RSA) was studied quantitatively during running for water reward and swimming. Scopolamine treatment caused a significant upward frequency shift of RSA during these behaviors. Thus, in contrast to previous reports it is concluded that anticholinergics do not leave movement associated RSA unaffected.