208 G2 block in irradiated cervix tumors

Uterine cervix carcinoma is one of the most common gynaecological malignancies in Portugal, accounting for 19.6% of all tumors in women. Considerable interpatient differences in radioresponse are observed in this condition, and thus it is important to evaluate the role that tumor radiosensitivity may play in determining treatment efficacy. The demonstration that some tumors are more radiosensitive than others may allow the selection of a subgroup that will need adjuvant therapy. The objective of this work was to verify the predictive value of DNA content and G2 phase fraction, evaluated by flow cytometry, on the outcome of fractionated radiotherapy. A significant radiation induced in G2 block was observed after one week of treatment, both in aneuploid and diploid tumors.