Comparison of 2 µg/kg of fentanyl and 150 µg/kg oxycodone during induction on post-intubation hemodynamics: a randomized clinical trial

Context: Endotracheal intubation may cause increased blood pressure and heart rate. The use of fentanyl as pre-intubation medication may blunt the hemodynamic changes. However, fentanyl has side effects of sedation and respiratory depression. Oxycodone is an opioid similar to fentanyl that may be used as preintubation medication with less effects on sedation and respiratory depression. Aims: This study aimed to compare the effect of 150 µg/kg oxycodone and 2 µg/kg fentanyl during induction on post-intubation blood pressure and heart rate changes. Methodology: The study was a double-blind, randomized clinical trial in 40 patients ASA I-II aged between 19-65 years old undergoing elective surgery under general anesthesia. The patients were divided into 2 groups, one receiving 150 µg/kg oxycodone and one receiving 2 µg/kg fentanyl during induction. Blood pressure and heart rate were recorded before induction (T0), before intubation (T1), just after intubation (T2), 3 min after intubation (T3) and 5 min after intubation (T4). Statistical data was analyzed using unpaired t-test and Mann-Whitney test, where p < 0.05 was considered significant. Results: The results showed significant differences (p < 0.05) in MAP ( and #61508;MAP) in every time points assessed (12.15  ±  6.753, 13.40  ±  6.143, and 17.59  ±  7.715 in oxycodone group versus 3.65  ±  3.746, 6.05  ±  4.186, and 9.40  ±  6.484 in fentanyl group, consecutively). This study also showed significant differences (p < 0.05) in heart rate in every time points assessed (3,40  ±  4.212, 8.35  ±  4,891 and 10.45  ±  6.253 in oxycodone group versus -4.80  ±  6.477, -2.15  ±  4.671, and -1.20  ±  6.978 in fentanyl group, consecutively). Conclusions: Administration of 150 µg/kg oxycodone during induction causes smaller increase in post-endotracheal intubation blood pressure and heart rate compared to 2 µg/kg fentanyl. Key words: Blood pressure; Fentanyl; Heart rate; Intubation; Oxycodone; Post-intubation hemodynamic Citation: Suwarman, Rismawan B, Rizky Heiry R. Comparison of 2 µg/kg of fentanyl and 150 µg/kg oxycodone during induction on post-intubation hemodynamics: a randomized clinical trial. Anaesth. pain intensive care 2021;25(1):71–75; DOI: 10.35975/apic.v25i1.1443 Received: 25 September 2020, Reviewed: 4 January 2021, Accepted: 10 January 2021