Spectral transfer function analysis of respiratory hemodynamic fluctuations predicts end-diastolic stiffness in preserved ejection fraction heart failure

We demonstrate that spectral transfer function analysis of gain between end-diastolic pressure and stroke volume is impaired in experimental preserved ejection fraction heart failure (HFpEF), validating previous exploratory clinical data. We further demonstrate a clear relation to end-diastolic stiffness, which suggests it may be used as a screening/diagnostic tool in HFpEF.