[The spatial-temporal organization of the membrane-synaptic modifications and of the topograms of the slow fluctuations in the cortical potentials during learning].

: This paper deals with an actual problem of specificity of organization of different stages of a conditioned reflex (CR). We suggest to consider this problem at the level of membrane-synaptic modifications comparing them with the indices of changes in the spatial organization of slow potentials in the cortex. The definite sequence of involvement of cellular mechanisms has been shown which can determine different features of the spatial organization of cortical slow potentials. Changes in cellular excitability of cortical neurons are probably connected with the variations of the general level of momentary electroencephalotopograms and, correspondingly, with the level of general spatial synchronization. Involvement of excitatory and inhibitory synaptic connections (with the efficiency corresponding to CR stages) determines the formation of electroencephalotopogram relief. Indices of both levels depend of hypothalamic effects on the cortex.