COVID-19 O-009 : Epidemiology and Clinical Features of Common Community Human Coronavirus Disease Before COVID-19

Backgrounds We would improve the understanding and management preparation of human coronavirus (HCoV) disease by analyzing the epidemiology, clinical aspects, and prognostic factors of patients of all ages who were recently hospitalized with coronavirus. Methods This study was retrospectively performed at five university teaching hospitals between 1 January 2018 and 31 March 2020. Routine molecular testing using for multiplex real-time reverse transcription-polymerase chain reaction Methods was conducted on the respiratory viruses. We assessed the demographics, laboratory findings, and treatment of patients infected with coronavirus. Results There were 807 coronavirus-infected patients admitted to five hospitals for 27 months and 553 (69%) of them were <10 years age. All-cause mortality rates of patients admitted for seasonal HCoV disease were 3.1% in all patients, and 10.8% in patients aged ≥ 18 years. The Cox proportional hazard regression analysis was performed in patients aged ≥ 18 years. After adjusting for other clinical variables, general weakness symptoms (hazard ratio [HR], 2.65; 95% confidence interval [CI], 1.14-6.13, P = 0.023) , National Early Waring Score (NEWS) ≥2 (HR, 6.00; 95% CI, 1.40-25.81, P = 0.016), and coronavirus subtype OC43 (HR, 2.82; 95% CI, 1.21-6.58, P = 0.016) were significantly associated with death from coronavirus. Conclusions Coronavirus infection can reveal a higher mortality rate in patients of ≥18 years than those of <18 years, thus, adult patients require more careful treatment. Furthermore, in adult patients, the factors associated with death from coronavirus include general weakness symptoms, NEWS higher than 2, and OC43 subtype.