Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

Feng Wang,Jordan C. Tsai,Jonathan H. Davis,Bryant Chau,Jia Dong,Sean M. West,Jason M. Hogan,Matthew L. Wheeler,Christine Bee,Winse Morishige,Thomas Cayton,Donata David-brown,Chengyue Zhang,Alexander T. Kozhich,Tim W. Sproul,Gavin Dollinger,Arvind Rajpal,Pavel Strop

Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

2020

Feng Wang
Jordan C. Tsai
Jonathan H. Davis
Bryant Chau
Jia Dong
Sean M. West
Jason M. Hogan
Matthew L. Wheeler
Christine Bee
Winse Morishige
Thomas Cayton
Donata David-brown
Chengyue Zhang
Alexander T. Kozhich
Tim W. Sproul
Gavin Dollinger
Arvind Rajpal
Pavel Strop

ABSTRACTThe development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the...

Keywords:

Antibody
Computational biology
Immune system
Biology
Immunology
Cancer research
bispecific antibody
syngeneic mouse

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