Valerenic and acetoxyvalerenic acid

Abstract Valerenic acid and acetoxyvalerenic acid, a monocarboxylic acid, are bicyclic sesquiterpenoid phytochemicals present in various plant species of Valeriana. These phytoconstituents have been found to produce various pharmacological activities including sedative, antidepressant, neurotoxic, sedative, anxiolytic, with roles in brain-derived neurotrophic factor (BDNF) and gastrointestinal (GIT) motility, etc. Valerenic acid could also affect the condition of Alzheimer’s disease, as assumed through an increase in BDNF expression.