The role of deferoxamine in the prevention of gentamicin ototoxicity: a histological and audiological study in guinea pigs

Conclusion. The addition of deferoxamine to gentamicin seems to confer partial functional and histological protection to the cochlea. Objective. Aminoglycosides are known ototoxic agents. The toxicity occurs via an activation process involving the formation of an iron–gentamicin complex with free radical production. Iron chelation will supposedly limit this toxic effect. This study aimed to determine the possible cochleoprotective role of deferoxamine on the ototoxic effect of gentamicin. Materials and methods. Sixty healthy active guinea pigs, weighing 400–600 g, with an average age of 6 months were used. They were divided into three groups. Group 1 received intramuscular gentamicin 8 mg/kg/day, group 2 received gentamicin 8 mg/kg/day and deferoxamine 150 mg/kg twice daily for 19 days and group 3 served as a control. All animals had a baseline measurement of distortion product autoacoustic emissions. At the end of 33 days they were submitted to another measurement and then the animals were sacrificed and...