Moderate radioprotective role of zeolite in rats
2019
Background/Aim. The goal of the study was to test if subacute administration
of micronized zeolite (MZC) accomplishes radioprotective role based on the
evaluation of the status of oxidative stress (OS) in the brain and
8-hydroxyguanosine (8-OH-dG) in plasma of rats exposed to the single γ-ray
irradiation of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a
four-week normal or 5% MZC supplemented diet and afterward exposed to the
single γ-ray irradiation of 2 and 10Gy. Groups of rats: a) on a normal diet:
the control group and 2Gy and 10Gy groups; b) on 5% MZC supplemented diet:
the control group - MZC, MZC+2Gy, and MZC+10Gy groups. We measured
malondialdehyde (MDA), glutathione (GSH) total, and activity of total and
manganese superoxide dismutase (tSOD and MnSOD) in vulnerable brain regions
(cerebellum, hippocampus, and cerebral cortex) and 8-OH-dG in plasma.
Results. Lower MDA was lower in MZC+2Gy and MZC+10Gy compared to 2Gy and 10Gy
groups. Total SOD was higher in MZC+10Gy than in 10Gy. GSH was the highest in
the 10Gy group. Compering to the control group, 8-OH-dG was extremely higher
in groups radiated with 10 Gy regardless of diet, but slightly lower in
MZC+2Gy and 2Gy groups. Conclusion. Subacute MZC pretreatment accomplished
partial radioprotective effect in rats based on suppressed SOD activity
compared to non-irradiated rats at 2 Gy, and reduced brain MDA at 2 and 10
Gy.
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