Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling

PI3K is a central component of the insulin signalling pathway. Here, the authors reveal that miR-378 expression in the liver changes dynamically in response to fasting or refeeding, and show that miR-378 regulates hepatic insulin signalling by targeting the P110a subunit of PI3K.