Изменения экспрессии коллагенов уретры при гипоспадии у детей

There are presented data of clinical and experimental studies of the expression of collagens in different techniques for surgical correction of hypospadias in children: by way of incision along urethral plate followed by tubularization (the technique of ''tubularized incised plate urethroplasty'' or TIP) and with the adding a graft to the raw area in the incised plate (TIPG). There was established functional improvement of the studied uroflowmetry parameters with increasing time after the correction of hypospadias by the urethroplasty technique of ''tubularized incised plate urethroplasty». An original experimental model of hypospadias for the study of biophysical properties of the urethra after the urethroplasty by direct measurement of pressure in the isolated urethral segment has been developed. For the first time there was established the absence of collagen type III in the bioptates of urethral plate in hypospadias in children, that leads to the disturbance of the formation of the elasticity of the urethra, determines the changes in indices of uroflowmetry in the postoperative period and may be a molecular criterion of efficacy of correction of hypospadias in children.