Histocompatibility antigens and their role in the pathogenesis of developmental anomalies of the nervous system in children

: Clinical and immunogenetic examinations of 40 patients with congenital diseases of the nervous system and of 10 couples of their parents revealed an association with HLA B12 antigen, HLA homozygosis in the majority of parents and children, and a high level of antigenic stimulation. The results may be considered as markers and criteria of a high risk of development of this disease in children.