The Effect of Single Dose Methylphenidate on Neurometabolites according to COMT Gene Val158Met Polymorphism in the Patient with Attention Deficit Hyperactivity Disorder: A Study Using Magnetic Resonance Spectroscopy.

Onder Ozturk,Huseyin Alacam,Burge Kabukcu Basay,Omer Basay,Ahmet Buber,Özlem İzci Ay,Kadir Agladioglu,Mehmet Emin Erdal,Hasan Herken

The Effect of Single Dose Methylphenidate on Neurometabolites according to COMT Gene Val158Met Polymorphism in the Patient with Attention Deficit Hyperactivity Disorder: A Study Using Magnetic Resonance Spectroscopy.

2016

Onder Ozturk
Huseyin Alacam
Burge Kabukcu Basay
Omer Basay
Ahmet Buber
Özlem İzci Ay
Kadir Agladioglu
Mehmet Emin Erdal
Hasan Herken

Objective Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Thus, the present study aimed to determine the effects of a single dose of methylphenidate (Mph) on neurometabolite levels according to polymorphisms of the catechol-O-methyltransferase (COMT) gene.

Keywords:

Neurodevelopmental disorder
Methylphenidate
Psychology
Endocrinology
Psychiatry
Catechol-O-methyl transferase
Attention deficit hyperactivity disorder
Internal medicine
Polymorphism (computer science)
Dorsolateral prefrontal cortex
Anterior cingulate cortex
Genotype
Medicine

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