New Inhibitors of Human Renin Tested in vitro and in vivo in the Anaesthetized Baboon

A new inhibitor of human renin (H.189) is described. It is a decapeptide analogue of human renin substrate with the amino acid, statine, substituted for leucine in the scissile bond. Its inhibitory potency as shown by IC50 is 1.0 x 10″6 M with human plasma renin and 1.5 x 10″8 M with baboon plasma r