ACCELERATION OF NUCLEIC ACID HYBRIDIZATION ON DNA MICROARRAYS DRIVEN BY pH TUNABLE MODIFICATIONS
2001
A series of peptides containing histidine residues were designed as potential hybridization rate enhancers within a polymeric matrix of DNA microarrays. The polymeric matrix modified with these peptides showed strong attraction to DNA molecules under conditions of induction. DNA probes on the peptide-modified sites rapidly hybridized to their complementary targets with single base pair mismatch discrimination.
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