Effects of Iron Supplementation on Iron Nutrition Status and Cognitive Functions in Children

This study examined the effect of iron supplementation on cognitive function by a double-blind intervention trial in nine-year-old mildly anaemic schoolchildren. Their nutritional status was assessed by anthropometric measurements and the following biochemical values: haemoglobin, haematocrit, red blood cell count (RBC), mean corpuscular haemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), serum iron, total iron-binding capacity (TIBC), and transferrin saturation. In addition, biochemical values of vitamin A, vitamin C, thiamine, riboflavin, pyridoxine, and zinc were measured. The cognitive assessment was performed using an abbreviated Wechsler Intelligence Scale for Children-Revised (WISC-R) containing six subtests: arithmetic, similarities, digit span, picture completion, block design, and digit symbol (coding), in order to obtain information on both verbal and non-verbal aspects of intelligence. There were highly significant correlations of the WISC-R sco...