Mutagen and Oncogen Study on 1-Methylaminoanthraquinone

Abstract : The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. 1- Methylaminoanthraquinone demonstrated significant genetic activity in two cell culture assays that measure gene mutation and DNA repair. Both assays responded to the chemical under activation test conditions and in one it produced activity without activation. No significant in vivo responses were obtained. If the test compound produces only gene mutation and primary DNA damage in mammalian cells it might be expected to be negative in the dominant lethal studies.