THE TRIAMINO-ANALOGUE OF METHYL CHOLATE; A FACIAL AMPHIPHILE AND SCAFFOLD WITH POTENTIAL FOR COMBINATORIAL AND MOLECULAR RECOGNITION CHEMISTRY

Abstract The triamino steroid 2 is synthesized from cholic acid ( 1 ), and found to possess little tendency to aggregate at pH 5 – 6 in aqueous solution. 2 and/or related derivatives are expected to find use in the synthesis of receptors and combinatorial libraries, and as “contrafacial amphiphiles” for drug delivery across cell membranes.