Abstract P061: Determinants of Incident Metabolic Syndrome and Type 2 Diabetes in Normal Weight: The Jackson Heart Study

New evidence suggests that individuals with normal weight at diagnosis of type 2 diabetes (T2D) are at higher risk for all-cause mortality than those who were overweight or obese at diagnosis. While investigation of the determinants of different diabetes risk categories among those with obesity has become more common, explanations beyond genetic predisposition for the heterogeneity in risk among those without obesity are lacking. We hypothesized that visceral fat and insulin resistance would be associated with incident metabolic syndrome (MetS) and T2D among African American individuals with normal weight. In 1,032 participants of the Jackson Heart Study with normal weight (BMI 18.5 – 24.9 kg/m2), we used logistic regression to investigate the determinants of incident MetS and T2D, separately. T2D and MetS were assessed at study visit 3 for the CT scan variables, and visits 2 and 3 for all other variables. We used the harmonized International Diabetes Federation criteria to define MetS. We excluded partic...