Bicyclic compound and pharmaceutical use

Strong intraocular pressure, eye irritation, to provide a side effect-free compound to the eye of aqueous humor protein increase like. The general formula (I) (Wherein, as. Described in the definition in the specification of each group), a compound represented by, a salt thereof or a solvate or a prodrug thereof, has a strong intraocular pressure-lowering effect, further, eye irritation sex (hyperemia, corneal opacity, etc.), since there is no side effect to the eye of aqueous humor protein increase and the like, it can be a prophylactic and / or therapeutic agent, such as high safety, and excellent glaucoma.