ИЗМЕНЕНИЯ ФУНКЦИОНАЛЬНЫХ ХАРАКТЕРИСТИК ТРОМБОЦИТОВ ПРИ ПРОВЕДЕНИИ ИНАКТИВАЦИИ ПАТОГЕНОВ В КОНЦЕНТРАТАХ ТРОМБОЦИТОВ (предварительное сообщение) И. М. Накастоев, А. Е. Грачев, Э. Г. Гемджян, М. А. Пантелеев, Н. В. Захарова, Е. А. Ватагина, И.С. Кастрикина, В. М. Погорелов, В. В. Рыжко

Summary T. he aim of the study was evaluation of the eff ects of amotosalen photodynamic inactivation of pathogens in platelet concentrates (PC) on the platelet function. Three groups of PC were analyzed: 1) native PC on the day of donation; 2) native PC after 20—24 h storage; and 3) PC after pathogen inactivation (PI) by the Intercept system 20—24 h after donation. Platelet counts, large and immature platelet fractions, phosphatidylserine (PS) and P-selection expression on inactivated platelet membranes and after their target stimulation were studied in all samples. Pathogen inactivation was associated with a signifi cant reduction of platelet concentrations in PC. Studies of PS and P-selectin expression showed that PI suppressed spontaneous stimulation of platelets during storage. However, direct stimulation of platelets was associated with a signifi cant reduction of PS expression in PC subjected to PI. The PI method used in our study led to reduction of cell concentrations in PC and modulated platelet function.Key words: platelet concentrate, pathogen inactivation. amotosalen, P-selectin, phosphatidylserine