Deciphering the Roles of C2-Domain-Containing Proteins (Synaptotagmins and Otoferlin) in the Inner Ear

Synaptic vesicle exocytosis is a highly regulated Ca2+-dependent form of SNARE-mediated membrane trafficking. The short time interval between presynaptic Ca2+ entry and vesicle fusion is made possible by high-affinity Ca2+-sensitive proteins that trigger exocytosis. Synaptotagmins (Syts) are a