The Comparison of 12 Weeks Continuous Training at Fatmax and Anaerobic Threshold Intensities and High Intensity Interval Training on Antioxidant Enzymes and Lipid Peroxidation Index in Pre-diabetic Patients

Background: Prediabetes state is associated with increased oxidative stress index and reduced of antioxidants. The aim of this study was to assess the effect of 12 weeks continuous training at Fatmax intensity and anaerobic threshold, and high-intensity interval training on antioxidant enzymes and lipid peroxidation index in pre-diabetic patients. Methods: Thirty-two pre-diabetic patients (age: 38.7 ± 4.0 yrs; body mass index: 26.9 ± 1.4 kg/m2; percent body fat (%): 26.1 ± 2.5; VO2Peak: 2.49 ± 0.22 l/min) were divided into 4 groups (n=8) control (CON), high-intensity interval training (HIT), continuous training at Fatmax intensity (FAT) and continuous training at anaerobic threshold (IAT) groups. Subjects of the HIT, FAT, and IAT groups run out their specific exercise training for 12 weeks. Blood Malondialdehyde (MDA), Superoxide Dismutase (SOD) and Catalase (CAT) were determined in the lab. The student’s t-test and ANCOVA were used to analyze the data. Results: The effect of exercise training on glucose concentration in FAT, IAT and HIT groups was 12%, 10% and 17%, respectively; the difference was significant in the training groups in comparison to CON group (p≤0.05). SOD and CAT in the training groups were significantly (p<0.05) increased when compared to the pre-training values. Also, FAT, IAT and HIT resulted in significant (p<0.05) changes in MDA compared to baseline. Conclusion: The training protocols had similar effects on the insulin resistance index in prediabetic patients. Also, continuous endurance training with low- to moderate-intensity and high intensity interval training are effective protocols for the modulation of antioxidant enzymes and lipid peroxidation index.