[Circadian rhythms of hypophysis-thyroid hormones secretion in patients with bronchial asthma].

AIM: To examine circadian rhythms of hypophysiothyroid system in patients with bronchial asthma and effects of exogenic glucocorticoids on thyroid function. MATERIALS AND METHODS: Free T3, T4 and TTH were measured in plasma using immunochemiluminescence in 16 patients with nonallergic bronchial asthma running a severe course. The plasma samples were taken each 6 hours for 48 hours. RESULTS: In patients with severe bronchial asthma (SBA) thyroid functional activity changed. Production of T3 increased while that of T4 dropped at night. TTH concentration rhythm for 24 hours was like that in healthy subjects. Glucocorticoids induced no significant changes in circadian rhythms of hypophysiothyroid system in SBA patients. CONCLUSION: In SBA functional activity of the hypophysiothyroid system changes with rearrangement of hormonal production at night.