New eudesmane sesquiterpenes from the marine-derived fungus Penicillium thomii

Abstract Four new eudesmane-type sesquiterpenes thomimarines A–D ( 1 – 4 ) were isolated from the marine-derived fungus Penicillium thomii. Their structures were established based on spectroscopic methods. The absolute configurations of 1 – 4 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Inhibitory effects of compounds 1 , 2 and 4 on NO production in LPS-induced RAW 264.7 murine macrophages were evaluated.