A study on ovulation inhibition by Quinestrol: one dose a month.

The efficacy and safety of Quinestrol in a single-dose-a-month regimen for inhibition of ovulation was studied. 10 women received 2 mg Quinestrol on Day 1 of the first treatment cycle and 2 mg Quinestrol plus 50 mg medroxyprogesterone (Provera) on Day 22. During treatment Cycles 2 3 and 4 2 mg Quinestrol plus 50 mg Provera were received on Day 22 and in Cycle 5 no medication was received. Basal body temperature urinary pregnanediol and urinary follicle-stimulating hormo ne determinations vaginal cytology and endometrial biopsies were performed during each cycle. The single 2 mg dose inhibited ovulation in 60% and delayed ovulation in 35% of a series of 40 cycles. The human safety laboratory studies did not reveal any abnormalities and the side effects were mild in nature. It was concluded that this regimen might prove adequate for more effective inhibition of ovulation with larger do ses of Quinestrol.