The major histocompatibility complex of rhesus monkeys. XIV. A family study of DR and other RhLA-linked cell membrane antigens.

The segregation of B-cell specific (Ia) determinants was studied in a large number of rhesus families. As expected, on the basis of results of a recent population study, the eight serologically defined DR antigens segregated as alleles of a single locus within RhLA. Two or three antigens not controlled by DR remained candidates for a second Ia series closely linked to DR. The 162 identifiable haplotypes provided interesting information regarding positive associations among antigens of two, three or even four sets of RhLA loci. Further, a new series of antigens closely linked to the RhLA-A locus could be postulated. Data obtained from 8 recombinant offspring permitted a better definition of the mapping position of all known loci of RhLA.