The Importance of Serum Total and Lipid-Bound Sialic Acid as Markers in Patients With Small Cell and Non-Small Cell Lung Carcinoma

Objectives: Serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were investigated in patients with small and non-small cell lung carcinoma and their role in discriminating small from non-small cell lung carcinoma and lung carcinoma from healthy individuals was evaluated. Patients and Methods: The study included 159 male patients with non-small cell lung carcinoma (n=102) and small cell lung carcinoma (n=57) who never received chemotherapy and/or radiotherapy and 35 healthy volunteers as controls. Serum TSA and LSA levels were determined by the methods of Warren and Katopodis, respectively. Results: Serum TSA and LSA levels in both patient groups were significantly elevated when compared with controls (palt;0.001), but the patient groups did not differ significantly in this respect. Receiver operating characteristic (ROC) analysis showed that TSA was more specific and LSA was more sensitive in distinguishing patients with non-small cell carcinoma from healthy individuals. On the other hand, LSA was found to be more sensitive in distinguishing patients with small cell carcinoma from healthy controls. Conclusion: Serum total and lipid-bound sialic acid may play an important role as biochemical markers in distinguishing patients with small and non-small cell lung carcinoma from healthy subjects. Turkish Baslik: Kucuk Hucreli ve Kucuk Hucreli Disi Akciger Kanserli Hastalarda Serum Total ve Lipide Bagli Siyalik Asidin Marker Olarak Onemi Anahtar Kelimeler: Kucuk hucreli akciger kanseri; kucuk hucreli disi akciger kanseri; total siyalik asit; lipide bagli siyalik asit; marker Amac: Kucuk hucreli ve kucuk hucreli disi akciger kanserli hastalarda serum total siyalik asit (TSA) ve lipide bagli siyalik asit (LSA) duzeyleri incelendi ve hastalari saglikli bireylerden ve birbirinden ayirmada bu parametrelerin marker olarak rolu irdelendi. Hastalar ve Yontemler: Calismaya henuz hic kemoterapi ve/veya radyoterapi almamis 102 kucuk hucreli disi ve 57 kucuk hucreli akciger kanserli toplam 159 erkek hasta ve 35 saglikli erkek gonullu dahil edildi. Serum TSA analizinde Warren yontemi, LSA analizinde Katopodis yontemi kullanildi. Bulgular: Kucuk hucreli ve kucuk hucreli disi akciger kanserli hastalarin serum TSA ve LSA duzeyleri sagliklilara gore anlamli olarak yuksekti (palt;0.001), ancak bu iki hasta grubu arasinda bu acidan anlamli farklilik bulunmadi. ROC (Receiver operating characteristic) analizinde, kucuk hucreli disi akciger kanserli hastalari sagliklilardan ayirmada TSAa#39;nin ozgullugunun, LSAa#39;nin ise duyarliliginin daha iyi oldugu goruldu. Ote yandan, kucuk hucreli akciger kanserli hastalari sagliklilardan ayirmada LSAa#39;nin daha duyarli oldugu saptandi. Sonuc:Serum total ve lipide bagli siyalik asit, kucuk hucreli ve kucuk hucreli disi akciger kanserli hastalari sagliklilardan ayirmada biyokimyasal marker olarak onemli rol oynayabilir.