Recombinant vectored vaccines

Abstract: Protective protein antigens from pathogenic bacteria or viruses can be cloned into other nonpathogenic organisms called vectors. If the vector cannot cause disease, then these recombinants can be used as vaccines. The most widely employed vectors used in animal vaccines are poxviruses such as vaccinia or canarypox. However, other vectors include adenoviruses, herpesviruses, and the insect viruses called baculoviruses. Vectors may also include some bacteria, yeasts, and even plants. These vectored vaccines are highly immunogenic and very safe. They have been widely and successfully used in many animal species. Vaccinia vectored vaccines have been used extensively to control rabies in wildlife.