A dihydroisoxazole-based route to 2,3,6-trideoxy-3-aminohexose derivatives

Abstract Acosamine and ristosamine derivatives were prepared via stereoselective reductive cleavage reactions of a benzylidenated dihydroisoxazolyl diol; the diol was prepared from 3-nitro-4,5-dihydroisoxazole via sequential propynylation, Lindlar reduction, and catalytic hydroxylation.