Trekrezan as a stimulator of muscle strength and endurance. Possible molecular mechanisms of action

Trekrezan activated the in vivo expression of the PGC-1α gene in rat muscle tissues. Quantification of mitochondria in tissues and gene expression analysis for genes involved in regulatory energy metabolism cascades revealed that the mechanisms of the energy metabolism regulation are probably coupled with protein biosynthesis as well as with innate immunity. The immunostimulatory and adaptogenic drug trekrezan was found to induce concerted in vivo stimulation of the expression of the gene coding tryptophanyl-tRNA synthetase and its activity in the expression of the PGC-1α gene.