A Convenient, Highly Selective and Eco-Friendly N-Boc Protection of Pyrimidines under Microwave Irradiation.

Protected pyrimidine nucleobases are of major importance as intermediates in the synthesis of nucleoside analogues and molecules with biological interests. We describe herein a novel practical microwave-assisted N-Boc protection of pyrimidine nucleobases under mild conditions using silica gel, avoiding treatment steps, and in increased yield.