Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles

This study demonstrates a direct role for synaptotagmin I in the endocytosis of synaptic vesicles that is distinct from its role in exocytosis. In addition, the authors find that either of the C2 domains of syt1 can act as a calcium sensor during endocytosis.