Pancreatic Excretion of Erythromycin and Kanamycin: Comparison of Results Obtained via a Thomas Cannula and a Duodenopancreaticopyelostoma in Dogs

Dainko and associates 1,2 in 1963 described a surgical technique for the collection of total pancreatic secretion from dogs. A duodenopancreaticopyelostoma, similar to the choledocho-ureterostoma of Pearce and Eisenbrey 3 and the cholecyst-nephrostoma of Kapsinow and colleagues, 4 was prepared as a two-stage procedure. The first operation consisted of hemisectioning the urinary bladder, bisecting the urethra, and placing the catheters through the abdominal wall from each hemibladder. One week later, the right kidney was removed and the major pancreatic duct with a 2-cm cuff of duodenal wall was anastomosed to the remaining right renal pelvis. Thus, pancreatic fluid drained from the right hemibladder, and urine from the remaining kidney drained from the left hemibladder. With this preparation Dainko and associates 1,2 studied the pancreatic excretion of several antibiotics given intravenously including erythromycin, 250 mg (two dogs); kanamycin sulfate, 180 mg (two dogs); and colistin sulfate, 25 mg (three dogs). High