Beneficial effects of cyclosporine on reoxygenation injury in hypoxic rat liver.

The effect of CeA on hypoxia-reoxygenation injury wae studied in perfused rat livers. CeA did not attenuate hypoxic injury, as assessed by the release of lactate dehydrogenaee and mitochondrial separtate aminotransferase. During reoxygenation, the release of lactate dehydrogenase was also not affected by CeA. However, the release of mitochondrial separtate aminotransferase into the cytosol, which indicates mitochondrial injury, was significantly reduced by CsA. The effect of CeA on mitochondrial function during hypoxia-reoxygenation was also investigated. CeA administration increased both the respiratory control ratio and the adenine nucleotide content after reoxygenation in both isolated mitochondria and perfused livers