Neuropsychiatric reaction induced by clarithromycin.

We read with interest the case report by Prime and French1 describing a person with HIV infection who developed a severe neuropsychiatric reaction during clarithromycin, zidovudine, didanosine, and nevirapine treatment. The authors suggest that this reaction was caused by the clarithromycin and not the antiretrovirals. Indeed, central nervous system (CNS) symptoms are a known side effect of clarithromycin.2 CNS adverse effects, however, have also been …