Benzoxazepine-Derived, Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

Gleb Andryianau,Michal Kowalski,Michal C. Piotrowicz,Adam A. Rajkiewicz,Barbara Dymek,Piotr L. Sklepkiewicz,Elżbieta Pluta,Filip Stefaniak,Wojciech Czestkowski,Sylwia Olejniczak,Marzena. Mazur,Piotr Niedziejko,Robert Koralewski,Krzysztof Matyszewski,Mariusz M. Gruza,Agnieszka Zagozdzon,Magdalena Salamon,Aleksandra Rymaszewska,Mikołaj Welzer,Karolina Dzwonek,Jakub Golab,Jacek Olczak,Agnieszka Bartoszewicz,Adam Golebiowski

Benzoxazepine-Derived, Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

2020

Human acidic mammalian chitinase (hAMCase) in one of two true chitinases in humans, the function of which remains elusive. In addition to the defense against highly antigenic chitin and chitin-cont...

Keywords:

Biology
Biochemistry
Chitin
Bioavailability
ACIDIC MAMMALIAN CHITINASE
hERG

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