Choroidal thickness and retinal vascular caliber correlations with internal carotid artery Doppler variables

Purpose Decreased retinal arteriolar caliber and increased retinal venular caliber have been associated with increased cardiovascular mortality. This study aimed to evaluate correlations of choroidal thickness and retinal vascular caliber measurements with internal carotid artery (ICA) Doppler ultrasound variables. Methods In this cross-sectional and observational study, 43 eyes and ICAs of 43 healthy volunteers were examined. Spectral domain optical coherence tomography was used to measure subfoveal choroidal thickness (SFCT) and retinal vascular caliber. The ICA Doppler ultrasonographic parameters were diameter, flow volume, peak-systolic velocity, end-diastolic velocity, resistance index (RI), and pulsatility index (PI). Results Negative correlations emerged between ICA RI and SFCT (p = 0.017, r = −0.36) as well as between ICA PI and retinal arteriolar caliber (p = 0.015, r = −0.37). A negative linear correlation appeared between ICA diameter and SFCT (p = 0.005, r = −0.42), although ICA diameter and flow volume showed no association with retinal vessel caliber (p > 0.05). Conclusions Choroidal thickness is negatively correlated with ICA diameter and ICA RI, while retinal arteriolar caliber is inversely related with ICA PI in normal volunteers. © 2015 Wiley Periodicals, Inc. J Clin Ultrasound 43:567–572, 2015